Where did the research begin?
From the pineal gland to melatonin: Pierpaoli describes the origins of his research.
Melatonin Zinc-Selenium
Let’s make melatonin clear!
A simple question deserves a clear answer. Bio-Clock began with this idea: understand melatonin, read the formula and make informed choices. This guide brings together themes from our archive, Walter Pierpaoli’s own words and current information about Melatonina Zinco-Selenio.
What is it, and how does it relate to sleep?
Melatonin is a hormone produced by the body in response to darkness. It helps time the sleep-wake cycle, the biological rhythm that follows day and night. The pineal gland is one of the sites where it is produced. Supplements provide melatonin from outside the body; the amount and timing matter.
Why melatonin, zinc and selenium?
The original Pierpaoli formula combines three components with different roles. Melatonin helps reduce the time it takes to fall asleep; the beneficial effect is obtained with 1 mg shortly before bedtime. Zinc contributes to normal immune function. Zinc and selenium help protect cells from oxidative stress. Each box contains 60 tablets. One tablet provides 1 mg melatonin, 8.7 mg zinc and 50 µg selenium.
Start with your evening routine
Our archive also explores light, habits and clock changes. Make room for a regular routine: consistent bedtimes, less bright light and fewer screens near bedtime, and attention to evening caffeine. A supplement is part of this wider picture. If sleep difficulties or repeated waking persist, speak to a health professional rather than increasing the dose yourself.
How do you take this formula?
For Melatonina Zinco-Selenio Pierpaoli, the manufacturer recommends one tablet in the evening, about half an hour before bedtime, preferably between 10 pm and midnight. These directions apply to this particular formulation. Ask a professional about shift work, medicines or personal needs. Check labels before combining products that contain melatonin.
A single box or a multipack?
Each box contains the same 60 tablets. The selector compares 1, 2, 3, 6, 12 or 24 boxes, showing the total price, price per box and saving. At the stated daily amount, one box mathematically supplies 60 days; this is not a recommended treatment duration. The product page calculates the cost per 30 days from your selected pack.
Research and today’s questions
In the original portal, Pierpaoli explores the pineal gland, the body clock, formulation choices and the role of zinc. The videos below preserve that historical testimony. Research hypotheses, particularly those concerning ageing, should be distinguished from demonstrated benefits and permitted supplement claims. Melatonin is not a promise of rejuvenation or a universal treatment.
Before you start
Do not exceed the recommended daily amount or take this product during pregnancy. Ask a doctor if you take medicines, are breastfeeding or are considering use for a child. Supplements do not replace a varied, balanced diet and a healthy lifestyle. Follow the warnings on the pack you receive. Forum posts and personal experiences cannot replace individual advice.
Continue in the Bio-Clock Magazine
- Pineal gland and body clock
- Caffeine and sleep
- Clock changes and habits
- Melatonin and the hormone question
Dr Pierpaoli’s bibliography: 140 references in our archive
Sources and current information
Pierpaoli formula leaflet · NCCIH: Melatonin · EU Regulation 432/2012
